Tresiba® Side Effects | Tresiba® (insulin degludec) injection 100 Units/mL, 200 Units/mL (2023)

FAQs

What are the common side effects of Tresiba? ›

Common side effects include diarrhea and headache, as well as swelling in the feet, legs, and ankles. Some serious side effects include hypoglycemia, hypokalemia, and severe allergic reaction. For more information about the different forms of insulin, talk with your doctor.

The most common side effects from Tresiba treatment include: hypoglycemia (low blood sugar levels) reactions at the injection site, such as redness, swelling, itchiness, or pain. nasopharyngitis (swelling of your nasal passages and the back of your throat)

You should not use Tresiba if you are allergic to insulin degludec, or if you are having an episode of hypoglycemia (low blood sugar) or diabetic ketoacidosis (call your doctor for treatment). Tresiba should not be given to a child younger than 1 year old. Tell your doctor if you are pregnant or breastfeeding.

Some people taking Tresiba may gain weight. In fact, weight gain is a common side effect of all insulins. It happens because of the way insulin works in your body. Insulin helps your liver, muscles, and fat cells remove excess sugar from your blood and store it for future use.

If you have certain types of liver disease or kidney disease, this could raise your risk for hypoglycemia from Tresiba. If you've had problems with your kidney or liver, talk with your doctor before using Tresiba. They may adjust your dose of Tresiba or monitor you more closely during your treatment. Allergic reaction.

What are the side effects of Tresiba Flextouch (Insulin Degludec)? Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin rash; wheezing, tiredness, trouble breathing; feeling like you might pass out; nausea, diarrhea; swelling of your face, lips, tongue, or throat.

Yes, Tresiba, like most insulins, can cause weight gain. People with type 1 diabetes gained an average of 1.8kg after 52 weeks. People with type 2 diabetes gained an average of 3.0kg after 52 weeks.

In a large safety study vs Lantus^® in adults with type 2 diabetes and heart disease, Tresiba^® did not increase their risk of major cardiovascular events, such as heart attack, stroke, or death.

A: No, adults using Tresiba can take their dose at any time of day. But when used in children, Tresiba should be given at the same time each day.

Because of the slow and steady way Tresiba breaks up and diffuses under the skin, it lasts for at least 42 hours. This means Tresiba can be dosed once a day, at any time of the day.

What drugs interact with Tresiba? ›

Dose increases and increased frequency of glucose monitoring may be required when TRESIBA is coadministered with these drugs. Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Pentamidine may cause hypoglycemia, which may sometimes be followed by hyperglycemia.

by Drugs.com

Tresiba is an ultra-long-acting human insulin analog (insulin degludec) that is given by subcutaneous injection (under the skin) for the treatment of diabetes in adults and children over the age of one year. Keep working for up to 42 hours.

Insulin: The Key Player in Belly Fat

Numerous hormones contribute to belly fat, but none proves more powerful than insulin, your fat storage hormone. High levels of insulin tell your body to gain weight around the belly, and you become more apple-shaped over time.

Diabetics should avoid fruits with a high GI or eat them in moderation so that their blood sugar levels do not spike abruptly. Pineapple, watermelon, mango, lychee, and banana have a high GI, so these are the worst fruits if you are diabetic.

“Eating enough protein while following a lower-carbohydrate diet can be an effective way to feel full, control blood sugar, improve insulin sensitivity, and ultimately, reduce or prevent belly fat,” Norwood says.

In healthy subjects, insulin has little or no effect on renal hemodynamics, glomerular filtration rate, or permeability to albumin. In patients with noninsulin-dependent diabetes, hyperinsulinemia selectively increases urinary albumin excretion.

Tresiba^® (insulin degludec) provides proven A1C reduction with once-daily dosing.

Do not stop using your insulin without talking to your doctor. If you stop using your insulin, this could lead to a very high blood sugar level and ketoacidosis (a condition with too much acid in the blood), see advice in section 4 'Too high blood sugar'.

The recommended starting dose of TRESIBA in insulin naïve patients with type 2 diabetes mellitus is 10 units once daily.

Tresiba is a great long-acting insulin option. It can be used for blood sugar control in people with Type 1 or Type 2 diabetes. It lasts the longest compared to other long-acting insulins. Long-acting insulins work similarly well at controlling blood sugar.

Where is the best place to inject Tresiba? ›

Choose an injection site on your thighs, abdomen (but not within 10cm of your belly button) or upper arm, and wipe it with an alcohol wipe. Let it dry. Do not use a site where the skin is discolored, bruised, broken, covered with a psoriatic lesion, or has a rash. Change (rotate) your injection site each injection.

Tresiba (insulin degludec) can last out of the fridge, at room temperature (below 86°F [30°C]), for 56 days (8 weeks). This includes Tresiba that is in-use (opened) and not in-use (unopened). After this time Tresiba should be discarded.

Opened (in-use) Tresiba^® should be refrigerated (36°F to 46°F [2°C to 8°C]) or kept at room temperature (below 86°F [30°C]), away from direct heat and light. Opened (in-use) Lantus^® SoloSTAR^® devices must be discarded 4 weeks after being opened.

The dose steps, however, differ between the two strengths of the medicinal product. With Tresiba 100 units/mL a dose of 1–80 units per injection, in steps of 1 unit, can be administered. With Tresiba 200 units/mL a dose of 2–160 units per injection, in steps of 2 units, can be administered.

Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk for a dangerous decrease in your blood sugar (hypoglycemia).

Can you take Tresiba (insulin degludec) and metformin together? Tresiba (insulin degludec) can be taken with other oral diabetes medications, like metformin, if your blood sugar level needs better control.

Combining insulin with medications like beta blockers, certain antibiotics, and other diabetes medications can increase the risk of low blood glucose. Beta blockers can even hide symptoms of low blood glucose, making the combination more dangerous.

Tresiba can also cause fluid retention, which can contribute to weight gain. Also, certain diabetes medications may cause fluid retention, weight gain, and rarely heart failure if they're used in combination with Tresiba. For more information, see the “Tresiba: Precautions” section below.

Adults can take once-daily Tresiba^® at any time of day and can decide on a time and place that works best. However, children must take their dose at the same time every day.

Typically, the dosage range for your total daily insulin dose is 0.2 to 0.4 units per kilogram of body weight. Your starting dosage of Tresiba for type 1 diabetes will depend on whether you're already using other forms of insulin.

Is 10 units of Tresiba a lot? ›

Recommended Starting Dosage in Patients with Type 2 Diabetes Mellitus: The recommended starting dose of TRESIBA in insulin naïve patients with type 2 diabetes mellitus is 10 units once daily.

The dose steps, however, differ between the two strengths of the medicinal product. With Tresiba 100 units/mL a dose of 1–80 units per injection, in steps of 1 unit, can be administered. With Tresiba 200 units/mL a dose of 2–160 units per injection, in steps of 2 units, can be administered.

Tresiba contains insulin degludec, an ultra-long-acting insulin that starts to work 60 minutes after administration and keeps working for up to 42 hours. Tresiba is approved for use in adults and children over the age of one with type 1 or type 2 diabetes.

After first use, Tresiba^® can be stored at room temperature (up to 86°F [30°C]) or in the refrigerator (36°F to 46°F [2°C to 8°C]) without the needle attached for a maximum of 8 weeks (56 days).

This side effect wasn't reported in the drug's clinical studies. However, diabetes, which Tresiba is used to treat, is known to cause hair loss. Medications that improve blood sugar levels, such as Tresiba, may lower your risk of hair loss caused by diabetes.

“Eating enough protein while following a lower-carbohydrate diet can be an effective way to feel full, control blood sugar, improve insulin sensitivity, and ultimately, reduce or prevent belly fat,” Norwood says.

Numerous hormones contribute to belly fat, but none proves more powerful than insulin, your fat storage hormone. High levels of insulin tell your body to gain weight around the belly, and you become more apple-shaped over time. Insulin also drives inflammation and oxidative stress, creating myriad downstream effects.